《黃舜平》醫師實驗室 / Dr. Shun-Ping Huang's Lab

本實驗室主要研究的目標是以探討眼部神經退化疾病的細胞與分子機轉並開發與測試具有治療潛力的藥物,及建立遺傳性退化疾病的基因分子診斷。我們希望藉由具有特定遺傳缺陷的疾病動物模式與臨床上所觀察到視網膜退化病患所表現的病理及基因的特徵的關聯性來深入探索致病機轉。長期的目標是希望能發展出針對視網膜病變特定致病基因的基因治療,開發優化的生物標記及利用人類誘導型多能幹細胞來進行臨床用藥的篩選或細胞治療。

To decipher the cellular and molecular mechanism of ocular neurodegeneration processes, to develop and test therapeutic strategies and to establish molecular genetic diagnosis of inherited retinal dystrophies are the major research goals in our lab. We investigate the pathophysiology and genetic profiles in retinal degenerations and relate the findings in human patients to those in animal models with homologous genetic defect. As recent advances in therapeutic research (particular gene therapy or human inducible pluripotent stem cell (iPS) therapy), our research is focused on evaluating the therapeutic success by short- and long-term follow-up in animal models, developing the optimized biomarkers and application procedures for future clinical trials.


遺傳性視網膜退化疾病的基因體研究與功能分析

Genomic and Functional analysis for hereditary retinal dystrophies

黃舜平 Dr. Shun-Ping Huang Research III

Retinitis pigmentosa (RP), a heterogeneous group of diseases with variable clinical manifestations, affects approximately 1 in 4,000 people worldwide. The dilemma in understanding RP is the question of how so many different and diverse primary genetic lesions causes the same clinical manifestation that characterizes RP. Information gained from the next generation sequencing-based genetic screening will directly aid in patients’ diagnosis, prognosis and treatment.

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研究與開發視神經保護的策略及藥物

Develop Therapeutic Strategies for Optic Neuropathies

黃舜平 Dr. Shun-Ping Huang Research II

We are interesting in investigating the different effects of neuroprotectants in animal disease model of optic neuropathies---the optic nerve crush model and rodent anterior ischemic optic neuropathy model. Our main goal is to study the pathophysiology of RGCs death in axon injury and to evaluate the neuroprotective mechanisms of potential therapeutic agents for optic neuropathies.

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探討自噬作用在眼部疾病扮演的角色

The Role of Autophagy in the Pathogenesis of Ocular Diseases

黃舜平 Dr. Shun-Ping Huang Research I

Autophagy is an intracellular self-degradative process to maintain cellular metabolism and homeostasis. Increasing studies have implicating deregulation of autophagy has been implicated in the pathogenesis of several ocular diseases, such as age-related macular degeneration, glaucoma, diabetic retinopathy. Our long-term goal is to study the function of autophagy in prevention of neuron cell damage and manipulate autophagy as a treatment against ocular neurodegeneration.

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